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Research & Development

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Despite significant progress in the development and distribution of vaccines, much remains to be accomplished. Infectious diseases remain the second leading cause of death and the leading cause of disability-adjusted life years worldwide (one disability-adjusted life year is one lost year of healthy life). Among children aged 0 to 4 years, infectious diseases cause approximately two thirds of all deaths worldwide. In 2001, approximately six million deaths were attributed to three diseases, for which no effective vaccines are available: AIDS, tuberculosis, and malaria. Effective vaccines also are lacking for many other serious infectious diseases that exact an enormous toll worldwide such as sexually transmitted diseases, parasitic diseases, respiratory pathogens, and gastroenteric-diarrheal diseases. In addition to endemic diseases, the world must cope with the ongoing threat of new and re-emerging diseases and the widespread development of antimicrobial resistance.


More than 50 newly recognized infectious diseases and syndromes have been identified since 1980, including AIDS and its etiologic agent, the human immunodeficiency virus (HIV). HIV has now infected well over 60 million people worldwide, of whom more than a third of have died. Certain other emerging infections, such as SARS, Ebola virus, and Nipah virus, are highly virulent but have so far involved relatively small numbers of people. Many of the “vaccine resistant” pathogens associated with these diseases exhibit the immunologic problem of Deceptive Imprinting. Hence, BMI is applying its Immune Dampening and Refocusing Technology to a select mix of human and veterinary diseases that have cross platforms, which offers enhanced synergy for the inputted research and development effort.

 

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Virus Developments

BMI is developing an AIDS vaccine and applying its Immune Dampening and Refocusing Technology to the outer HIV envelope glycoprotein gp120/gp41, which is the main mediator of viral fusion and entry with host receptors CD4 and chemokine receptors CCR5 and/or CXCR4.

The Latest Technology

Biological Mimetics, Inc. (“BMI”) was formed to commercialize innovative pharmaceutical products that will improve the quality of life and overall state of public health by combating resistant and emerging diseases in human and veterinary medicine. Our mission philosophy is to remain a creative and innovative biotechnology firm dedicated to improving the quality of life and overall state of public health through the application of novel technologies for the development and commercialization of human and veterinary biologics to address a long list of hitherto intractable disease targets involving viruses, bacteria, parasites, and cancer.

Research & Development

dreamstime_13272506Biological Mimetics, Inc. research and development includes veterinary applications such as:
Foot and Mouth Disease Virus , Infectious Pancreatic Necrosis Virus,
and Porcine Reproductive and Respiratory Syndrome Virus.

Company News

blk triangleJune 2011: BMI announces collaborative research agreement with Crucell-BV for development of a universal influenza vaccine
blk triangleNov. 2010: BMI announces collaborative research agreement with GSK-Biologicals for development of an immune refocused vaccine for respiratory infection
blk triangleSept 2010: BMI is awarded a Qualifying Therapeutic Discovery Project Award
blk triangleJune 2010: BMI is awarded a Small Business Innovative Research Grant from the NIH for vaccine development
blk triangleNov. 2009: BMI is a prime contractor in the Fundamentals of Biology Program of DARPA/DSO for the study of modularity in biological systems
blk triangleMay 2008: BMI is awarded a subcontract for HIV vaccine development through the Henry M Jackson Institute for the Advancement of Military Medicine.
blk triangleJuly 2007: BMI is awarded a subcontract from DARPA through Rice University to study the evolution of pathogens
blk triangleJune 2007: BMI is awarded a subcontract from DARPA through VaxDesign (Orlando, Florida) to study immunogenicity of influenza