|WHAT WE DO||WE COLLABORATE TO HELP YOU|
BMI Scientists are the inventors of the Immune Refocusing Technology, a method for the rational design of antigens.
At BMI, we apply novel and proprietary algorithms to better understand the antigenic nature of pathogens and proteins.
The methods focus on identifying epitopes (decoy epitopes) that stimulate strain-specific, non-protective, or disease-enhancing immunity.
These insights help lead us to design novel antigens in which the decoy epitopes have been modified to reduce their antigenic hierarchy. The new antigens stimulate novel immune responses with enhanced antiviral or antibacterial activities.Immune Refocusing is a Platform Technology. The rationally designed antigens can be introduced into virus vectors, recombinant bacteria, or purified as recombinant subunits. IRT has been developed primarily for the design of improved vaccines and antibodies.
BMI Scientists have examined scores of pathogens for application of IRT methods. In general, if a vaccine provides strain-specific or no protection, it is a candidate for IRT improvements. After identifying the pathogen, BMI will review the known literature and unpublished results regarding antigenic epitopes, structure, functional domains, and existing vaccines and design a small set of IRT candidates which can be tested in various preclinical model systems.
In its 16 years of business, BMI has derived proof of concept data on human and veterinary pathogens such as HIV-1, FMDV, Influenza, Non-typeable hemophilus influenza, IPNV, PRRS, coxidia, and malaria. In addition, BMI has performed preliminary IRT analysis on numerous pathogens including many of the NIAID Category A, B, and C Agents as well as those for which we currently have suboptimal vaccines (influenza, polio, HepB, etc.).
BMI recognizes that the IRT method may have its greatest potential in the design of antigens for the derivation of novel and improved antibodies. BMI welcomes new relationships for co-development of therapeutic and prophylactic antibodies for infectious diseases and cancer applications.